Automated glycopeptide assembly by combined solid-phase peptide and oligosaccharide synthesis

Chem Commun (Camb). 2014 Feb 21;50(15):1851-3. doi: 10.1039/c3cc48761j. Epub 2014 Jan 9.

Abstract

Current strategies for the synthesis of glycopeptides require multiple manual synthetic steps. Here, we describe a synthesis concept that merges solid phase peptide and oligosaccharide syntheses and can be executed automatically using a single instrument.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Automation
  • Glycopeptides / chemical synthesis*
  • Glycopeptides / chemistry
  • Monosaccharides / chemistry
  • Oligosaccharides / chemical synthesis*
  • Oligosaccharides / chemistry
  • Solid-Phase Synthesis Techniques / methods*

Substances

  • Amino Acids
  • Glycopeptides
  • Monosaccharides
  • Oligosaccharides