Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease

Int Microbiol. 2013 Jun;16(2):87-92. doi: 10.2436/20.1501.01.183.

Abstract

Prc is a periplasmic protease involved in processing of penicillin-binding protein 3 (PBP3). Lack of Prc suppresses bile sensitivity in Dam-, Wec-, PhoP-, DamX-, and SeqA- mutants of Salmonella enterica, and increases bile resistance in the wild type. Changes in the activity of penicillin binding proteins PBP3, PBP4, PBP5/6 and PBP7 are detected in a Prc- background, suggesting that peptidoglycan remodeling might contribute to bile resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Bile / chemistry
  • Bile Acids and Salts / pharmacology*
  • Humans
  • Mutation*
  • Penicillin-Binding Proteins / genetics
  • Penicillin-Binding Proteins / metabolism
  • Peptide Hydrolases / deficiency*
  • Peptide Hydrolases / genetics
  • Periplasm / enzymology*
  • Periplasm / genetics
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / enzymology*
  • Salmonella typhimurium / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Bile Acids and Salts
  • Penicillin-Binding Proteins
  • Peptide Hydrolases