Chemotherapy for advanced colorectal cancer has developed remarkably in recent years. However, medical practitioners are occasionally unwilling to initiate a standard multi-agent chemotherapy regimen for patients whose general condition is poor. We report the case of a patient with aggressively growing liver metastases and impending organ failure and symptoms who was successfully treated with the induction of anti-epidermal growth factor receptor( EGFR) antibody single- agent therapy. With the selection of some biomarkers, induction with anti-EGFR antibody single-agent therapy might be a beneficial therapeutic option for the treatment of colorectal cancer in patients with imminent organ failure and severe symptoms caused by local tumor progression.