Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?

Liver Int. 2014 Jul;34(6):e10-8. doi: 10.1111/liv.12457. Epub 2014 Jan 27.

Abstract

When cells are subjected to stress by changes in their extracellular environment, unfolded proteins accumulate in the endoplasmic reticulum (ER), causing ER stress. This initiates the unfolded protein response (UPR), a signal transduction cascade aiming at restoring cellular homeostasis. The UPR and angiogenesis are involved in the pathogenesis of many diseases such as cancer, pulmonary diseases and chronic liver diseases (CLDs) including alcoholic liver disease, non-alcoholic steatohepatitis and hepatitis B. This review summarizes the upcoming knowledge of the interaction between the UPR and angiogenesis in physiological angiogenesis and in different CLDs and other diseases.

Keywords: angiogenesis; cirrhosis; endoplasmic reticulum stress; liver diseases; unfolded protein response; vascular endothelial growth factor A.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Endoplasmic Reticulum / metabolism*
  • Endoplasmic Reticulum / pathology
  • Endoplasmic Reticulum Stress*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Liver / blood supply*
  • Liver / metabolism*
  • Liver / pathology
  • Liver Diseases / metabolism*
  • Liver Diseases / pathology
  • Liver Diseases / physiopathology
  • Neovascularization, Pathologic*
  • Neovascularization, Physiologic*
  • Signal Transduction
  • Unfolded Protein Response

Substances

  • Intracellular Signaling Peptides and Proteins