Abstract
The antibiotic elansolid B1 was prepared by a convergent strategy that relied on a highly diastereoselective, biomimetic intramolecular Diels-Alder cycloaddition (IMDA) that furnished the tetrahydroindane unit. Other key features are a double Sonogashira cross-coupling and a substrate-controlled Yamamoto aldol reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Biomimetics
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Macrolides / chemical synthesis*
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Macrolides / chemistry
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Models, Molecular
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Molecular Structure
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Stereoisomerism
Substances
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Anti-Bacterial Agents
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Macrolides
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elansolid B1