External validation of a model for periconceptional prediction of recurrent early-onset preeclampsia

Hypertens Pregnancy. 2014 Aug;33(3):265-76. doi: 10.3109/10641955.2013.872253. Epub 2014 Jan 6.

Abstract

Objective: To validate a previously published prediction model for recurrent early-onset preeclampsia (PE).

Methods: We included 229 pregnant women with a history of early-onset PE and computed their risk using the prediction model, compared the predicted risk to their pregnancy outcomes and assessed performance of the model.

Results: Early-onset PE recurred in 6.6% of participants. The area under the receiver operating characteristic curve was 59% (95% CI: 45-73). The model created groups that were only moderately different in terms of their risk.

Conclusions: The model's discriminate ability was poor and predictive performance insufficient to classify women into relevant risk groups.

Keywords: Early-onset; External validation; Prediction; Preeclampsia; Recurrence..

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adult
  • Female
  • Humans
  • Models, Theoretical
  • Pre-Eclampsia / diagnosis*
  • Predictive Value of Tests
  • Pregnancy
  • Recurrence
  • Registries
  • Risk Assessment