A review of maternally inherited diabetes and deafness

Front Biosci (Landmark Ed). 2014 Jan 1;19(5):777-82. doi: 10.2741/4244.

Abstract

Maternally inherited diabetes and deafness (MIDD), a mitochondrial disease first described in 1992, results from the mitochondrial DNA mutation and affects up to 1% of the patients with diabetes. This review discusses the biomedical mechanisms of MIDD patients; summarizes the recent improvement of clinical and genetic diagnosis of MIDD; outlines the advances of the clinical management of these patients and their families.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA, Mitochondrial / genetics
  • Deafness / diagnosis*
  • Deafness / genetics
  • Deafness / physiopathology
  • Deafness / therapy
  • Diabetes Mellitus, Type 2 / diagnosis*
  • Diabetes Mellitus, Type 2 / genetics
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetes Mellitus, Type 2 / therapy
  • Female
  • Humans
  • Mitochondrial Diseases
  • Molecular Diagnostic Techniques
  • Mutation
  • Pregnancy

Substances

  • DNA, Mitochondrial

Supplementary concepts

  • Noninsulin-dependent diabetes mellitus with deafness