Tocolysis for preterm labor: expert opinion

Arch Gynecol Obstet. 2014 Apr;289(4):903-9. doi: 10.1007/s00404-013-3137-9. Epub 2014 Jan 3.

Abstract

Tocolysis is an important treatment in the improvement of outcome in preterm labor and preterm birth, provided that its use follows clear evidence-based recommendations. In this expert opinion, the most recent evidence about efficacy and side effects of different tocolytics is being reviewed and evidence-based recommendation about diagnosis and treatment of preterm labor is given. Further aspects such as progesterone administration or antibiotic treatment for the prevention of preterm birth are included. Our review demonstrates that an individualized choice of different tocolytics and additional treatments is necessary to improve short- and long-term neonatal outcome in preterm labor and preterm birth.

Publication types

  • Practice Guideline
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Bed Rest
  • Calcium Channel Blockers / therapeutic use
  • Cervical Length Measurement
  • Contraindications
  • Cyclooxygenase Inhibitors / therapeutic use
  • Drug Approval
  • Female
  • Fenoterol / therapeutic use
  • Fetal Membranes, Premature Rupture
  • Hexoprenaline / therapeutic use
  • Humans
  • Infant, Newborn
  • Kalanchoe
  • Labor Stage, First
  • Magnesium Sulfate / therapeutic use
  • Nitric Oxide Donors / therapeutic use
  • Obstetric Labor, Premature / drug therapy*
  • Phytotherapy
  • Pregnancy
  • Premature Birth / prevention & control*
  • Progesterone / therapeutic use
  • Progestins / therapeutic use
  • Receptors, Oxytocin / antagonists & inhibitors
  • Tocolysis*
  • Tocolytic Agents / therapeutic use*
  • Ultrasonography, Prenatal

Substances

  • Anti-Bacterial Agents
  • Calcium Channel Blockers
  • Cyclooxygenase Inhibitors
  • Nitric Oxide Donors
  • Progestins
  • Receptors, Oxytocin
  • Tocolytic Agents
  • Fenoterol
  • Progesterone
  • Magnesium Sulfate
  • Hexoprenaline