EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium

J Invest Dermatol. 2014 Apr;134(4):1158-1161. doi: 10.1038/jid.2013.467. Epub 2013 Nov 11.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Animals
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / chemistry*
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / chemistry
  • CD4-Positive T-Lymphocytes / drug effects
  • Coculture Techniques
  • Diazonium Compounds / administration & dosage
  • Diazonium Compounds / chemistry*
  • Dose-Response Relationship, Drug
  • Epithelium / drug effects*
  • Epithelium / metabolism
  • Farnesol / administration & dosage
  • Farnesol / analogs & derivatives*
  • Farnesol / chemistry
  • HIV Infections / prevention & control*
  • HIV-1 / drug effects
  • Humans
  • Langerhans Cells / cytology
  • Langerhans Cells / drug effects*
  • Langerhans Cells / virology
  • Mice
  • Reverse Transcriptase Inhibitors / administration & dosage
  • Reverse Transcriptase Inhibitors / chemistry*
  • Skin / drug effects
  • Skin / metabolism

Substances

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Diazonium Compounds
  • Reverse Transcriptase Inhibitors
  • epoxyfarnesyl diazoacetate
  • Farnesol