Endocytic pH-triggered degradation of nanoengineered multilayer capsules

Kang Liang; Georgina K Such; Angus P R Johnston; Zhiyuan Zhu; Hirotaka Ejima; Joseph J Richardson; Jiwei Cui; Frank Caruso

doi:10.1002/adma.201305144

Endocytic pH-triggered degradation of nanoengineered multilayer capsules

Adv Mater. 2014 Mar 26;26(12):1901-5. doi: 10.1002/adma.201305144. Epub 2013 Dec 27.

Authors

Kang Liang¹, Georgina K Such, Angus P R Johnston, Zhiyuan Zhu, Hirotaka Ejima, Joseph J Richardson, Jiwei Cui, Frank Caruso

Affiliation

¹ Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.

PMID: 24375946
DOI: 10.1002/adma.201305144

Abstract

The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake.

Keywords: biomaterials; drug delivery; layer-by-layer; nanotechnology; polymer capsules.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell-Penetrating Peptides / chemistry
Drug Carriers / chemistry*
Extracellular Space / chemistry
Feasibility Studies
Flow Cytometry
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Intracellular Space / chemistry*
Microscopy, Confocal
Microscopy, Fluorescence
Molecular Weight
Nanocapsules / chemistry*
Phosphorylcholine / analogs & derivatives
Phosphorylcholine / chemistry
Polymethacrylic Acids / chemistry
Time Factors

Substances

Cell-Penetrating Peptides
Drug Carriers
Nanocapsules
Polymethacrylic Acids
poly(2-(diisopropylamino)ethyl methacrylate)
poly(MPC-co-MA)
Phosphorylcholine