The evaluation of the biomedical effectiveness of poly(amido)amine dendrimers generation 4.0 as a drug and as drug carriers: a systematic review and meta-analysis

Marian Jędrych; Katarzyna Borowska; Ryszard Galus; Barbara Jodłowska-Jędrych

doi:10.1016/j.ijpharm.2013.12.033

The evaluation of the biomedical effectiveness of poly(amido)amine dendrimers generation 4.0 as a drug and as drug carriers: a systematic review and meta-analysis

Int J Pharm. 2014 Feb 28;462(1-2):38-43. doi: 10.1016/j.ijpharm.2013.12.033. Epub 2013 Dec 25.

Authors

Marian Jędrych¹, Katarzyna Borowska², Ryszard Galus³, Barbara Jodłowska-Jędrych⁴

Affiliations

¹ Department of Mathematic and Biostatistic, Medical University of Lublin, 4 Jaczewskiego Street, 20-090 Lublin, Poland.
² Department of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego Street, 35-325 Rzeszów, Poland. Electronic address: k_borowska@wp.pl.
³ Department of Histology and Embryology, Center for Biostructure, Medical University of Warsaw, Chałubinskiego 5 Street, 02-004 Warsaw, Poland.
⁴ Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, 11 Radziwiłowska Street, 20-080 Lublin, Poland.

PMID: 24374222
DOI: 10.1016/j.ijpharm.2013.12.033

Abstract

The purpose of this study was to investigate the evaluation of the biomedical effectiveness of poly(amido)amine dendrimers generation 4.0 (PAMAM G4) as a drug and as drug carriers by a systematic review of literature and meta-analysis. The results obtained from meta-analysis concluded that drug therapy reduces the change of parameters in relation to the control. The impact of the drug administered to change the test parameters are dependent on the type of tissue. PAMAM G4 may be effective in vitro and in vivo as a drug and drug carriers and may have appropriate applications in various fields of medicine. PAMAM G4 dendrimers hold promises for nanomedicine.

Keywords: Generation 4.0; Meta-analysis; PAMAM G4; Poly(amido)amine dendrimers; Review.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Animals
Dendrimers / administration & dosage*
Dendrimers / chemistry
Dendrimers / pharmacology
Drug Carriers / chemistry*
Humans
Nanomedicine*
Nylons / chemistry
Nylons / pharmacology

Substances

Dendrimers
Drug Carriers
Nylons
PAMAM-G4