The MTHFD1 1958G>A variant is associated with elevated C-reactive protein and body mass index in Canadian women from a premature birth cohort

Mol Genet Metab. 2014 Mar;111(3):390-392. doi: 10.1016/j.ymgme.2013.12.004. Epub 2013 Dec 11.

Abstract

MTHFD1 1958G>A, a polymorphism in folate metabolism, increases risk of pregnancy complications. A mouse model exhibited developmental defects, increased weight and decreased leukocyte counts. To examine the latter associations, we genotyped 651 women from a premature birth cohort. Prematurity and 1958G>A were not associated. Increases in the inflammatory marker CRP (logistic regression, p = 0.055) and BMI (chi-square, p = 0.0113) were associated with AA genotype in women with low folate. MTHFD1 1958G>A may influence immune function and obesity.

Keywords: Body mass index; C-reactive protein; Folate; MTHFD1; Obesity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Mass Index
  • C-Reactive Protein / biosynthesis*
  • Canada
  • Female
  • Folic Acid / genetics
  • Folic Acid / metabolism*
  • Genetic Association Studies
  • Genotype
  • Humans
  • Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics*
  • Mice
  • Minor Histocompatibility Antigens
  • Obesity / genetics
  • Obesity / pathology
  • Polymorphism, Single Nucleotide
  • Pregnancy
  • Premature Birth / genetics*
  • Premature Birth / pathology
  • Weight Gain / genetics

Substances

  • Minor Histocompatibility Antigens
  • C-Reactive Protein
  • Folic Acid
  • MTHFD1 protein, human
  • Methylenetetrahydrofolate Dehydrogenase (NADP)