Abstract
Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY experiments supported by quantum chemical calculations. In vitro toxicity tests showed that pentahydroxyscirpene inhibits protein synthesis as do other trichothecenes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Fusarium / chemistry*
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Molecular Conformation
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Molecular Structure
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Mycotoxins / chemistry
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Mycotoxins / isolation & purification*
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Mycotoxins / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Oryza / microbiology
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Protein Synthesis Inhibitors / chemistry
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Protein Synthesis Inhibitors / isolation & purification*
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Protein Synthesis Inhibitors / pharmacology
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Trichothecenes / chemistry
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Trichothecenes / isolation & purification*
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Trichothecenes / pharmacology
Substances
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Mycotoxins
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Protein Synthesis Inhibitors
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Trichothecenes
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pentahydroxyscirpene