Abstract
From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Allylbenzene Derivatives
-
Anisoles / chemistry
-
Anisoles / isolation & purification*
-
Anisoles / pharmacology
-
Antifungal Agents / chemistry
-
Antifungal Agents / isolation & purification*
-
Antifungal Agents / pharmacology
-
Aspergillus / drug effects
-
Bignoniaceae / chemistry*
-
Candida / drug effects
-
Cryptococcus neoformans / drug effects
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Glycosides / pharmacology
-
Humans
-
Microbial Sensitivity Tests
-
Microsporum / drug effects
-
Molecular Structure
-
Naphthoquinones / chemistry
-
Naphthoquinones / isolation & purification*
-
Naphthoquinones / pharmacology
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology
-
Plant Roots / chemistry
-
Trichophyton / drug effects
Substances
-
Allylbenzene Derivatives
-
Anisoles
-
Antifungal Agents
-
Glycosides
-
Naphthoquinones
-
Plant Extracts
-
estragole
-
lapachol