Fe5C2 nanoparticles with high MRI contrast enhancement for tumor imaging

Small. 2014 Apr 9;10(7):1245-9. doi: 10.1002/smll.201303263. Epub 2013 Dec 18.

Abstract

An ancient material for magnetic resonance (MR) imaging: For the first time, Fe5C2 is prepared as colloidal stable nanoparticles with good aqueous stability. The nanoparticles boast strong magnetization, excellent chemical inertness, low toxicity, and one of the highest r2 relaxivities reported to date. These nanoparticles hold great potential in MR imaging as well as in other biomedical areas.

Keywords: integrins; iron carbides; magnetic properties; magnetic resonance imaging; nanoparticles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbon Compounds, Inorganic*
  • Cell Line, Tumor
  • Contrast Media*
  • Humans
  • Iron Compounds*
  • Magnetic Resonance Imaging*
  • Mice
  • Nanoparticles* / ultrastructure
  • Neoplasms / diagnosis*
  • Phantoms, Imaging

Substances

  • Carbon Compounds, Inorganic
  • Contrast Media
  • Iron Compounds
  • iron carbide