In vivo virtual intraoperative surgical photoacoustic microscopy

Seunghoon Han; Changho Lee; Sehui Kim; Mansik Jeon; Jeehyun Kim; Chulhong Kim

doi:10.1063/1.4830045

In vivo virtual intraoperative surgical photoacoustic microscopy

Appl Phys Lett. 2013 Nov 11;103(20):203702. doi: 10.1063/1.4830045.

Authors

Seunghoon Han¹, Changho Lee², Sehui Kim¹, Mansik Jeon², Jeehyun Kim¹, Chulhong Kim³

Affiliations

¹ School of Electrical Engineering and Computer Science, Kyungpook National University, Daegu 702-701, South Korea.
² Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, South Korea.
³ Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, South Korea ; Department of Biomedical Engineering, The State University of New York at Buffalo, Buffalo, New York 14221, USA.

Abstract

We developed a virtual intraoperative surgical photoacoustic microscopy system by combining with a commercial surgical microscope and photoacoustic microscope (PAM). By sharing the common optical path in the microscope and PAM system, we could acquire the PAM and microscope images simultaneously. Moreover, by employing a beam projector to back-project 2D PAM images onto the microscope view plane as augmented reality, the conventional microscopic and 2D cross-sectional PAM images are concurrently mapped on the plane via an ocular lens of the microscope in real-time. Further, we guided needle insertion into phantom ex vivo and mice skins in vivo.