Abstract
Aim:
To present the research results concerning enhanced antimicrobial and release properties of the chitosan derivative with sulfadiazine/hyaluronic acid polyelectrolyte complex (PEC) hydrogel.
Material and methods:
The PECs have been prepared from chitosan of different molecular weight, sulfadiazine chitosan derivative and sodium hyaluronate. The complex structure was assessed by FT-IR spectroscopic method and swelling capacity was followed by weighing measurements.
Results:
It has been establish that chitosan derivative influenced both PEC properties and swelling capacity.
Conclusions:
Incorporation in PEC of the sulfadiazine chitosan is a new way to combine bacteriostatic effect of chitosan with that of sulfadiazine, to control properties, antimicrobial activity in the treatment of the wound.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Bandages
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry
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Biocompatible Materials / pharmacology*
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Chitosan / chemical synthesis
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Chitosan / chemistry
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Chitosan / pharmacology*
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Drug Therapy, Combination / methods
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Electrolytes / chemistry
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Hyaluronic Acid / chemical synthesis
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Hyaluronic Acid / chemistry
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Hyaluronic Acid / pharmacology*
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Spectrophotometry, Infrared / methods
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Sulfadiazine / chemical synthesis
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Sulfadiazine / chemistry
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Sulfadiazine / pharmacology*
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Viscosupplements / chemical synthesis
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Viscosupplements / chemistry
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Viscosupplements / pharmacology*
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Wound Healing / drug effects*
Substances
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Anti-Infective Agents
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Biocompatible Materials
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Electrolytes
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Viscosupplements
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Sulfadiazine
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Hyaluronic Acid
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Chitosan