New furoquinoline alkaloids from the leaves of Evodia lepta

Fitoterapia. 2014 Jan:92:270-3. doi: 10.1016/j.fitote.2013.12.002. Epub 2013 Dec 9.

Abstract

Three new furoquinoline alkaloids, leptanoines A-C (1-3) along with three known compounds (4-6) were isolated from the leaves of Evodia lepta. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Compound 4 showed the highest inhibitory activity towards BChE with an IC50 value of 47.9 μM. On the other hand, Compound 5 showed the highest inhibitory activity towards AChE with an IC50 value of 69.1 μM.

Keywords: AChE and BChE activities; Evodia lepta; Furoquinoline alkaloids; Rutaceae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Butyrylcholinesterase / metabolism
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification*
  • Cholinesterase Inhibitors / pharmacology
  • Evodia / chemistry*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Leaves / chemistry*

Substances

  • Cholinesterase Inhibitors
  • Plant Extracts
  • Acetylcholinesterase
  • Butyrylcholinesterase