No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents

J Alzheimers Dis. 2014;40(1):37-43. doi: 10.3233/JAD-131841.

Abstract

Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.

Keywords: Apolipoprotein E; hippocampal volume; magnetic resonance imaging; young healthy adolescents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Apolipoprotein E4 / genetics*
  • Apolipoproteins E / genetics*
  • Cohort Studies
  • Female
  • Hippocampus / anatomy & histology*
  • Humans
  • Magnetic Resonance Imaging
  • Male

Substances

  • Apolipoprotein E4
  • Apolipoproteins E