Molecular characteristics of MDR Mycobacterium tuberculosis strains isolated in Fujian, China

Tuberculosis (Edinb). 2014 Mar;94(2):159-61. doi: 10.1016/j.tube.2013.03.004. Epub 2013 Dec 8.

Abstract

Of 75 MDR isolates from Fujian Province, the sensitivity of RIF, INH, EMB, SM, OFLX and KAN resistance by DNA sequencing was 96.0%, 96.0%, 66.7%, 66.0%, 84.2% and 75.0%, respectively. We also identified that minority mutations in the mixed Mycobacterium tuberculosis population may be responsible for two "false-negative" results. In addition, Beijing genotype is still the predominant sublineage in the MDR TB cases from Fujian.

Keywords: MDR; Molecular characteristics; Mycobacterium tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antitubercular Agents / pharmacology*
  • Bacterial Proteins / drug effects
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / immunology
  • Bacterial Proteins / isolation & purification
  • Catalase / drug effects
  • Catalase / genetics*
  • Catalase / immunology
  • China / epidemiology
  • DNA, Bacterial / isolation & purification
  • Drug Resistance, Bacterial / genetics
  • False Negative Reactions
  • Female
  • Gene Deletion
  • Humans
  • Hydrolases / drug effects
  • Hydrolases / genetics*
  • Hydrolases / immunology
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mutation
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / isolation & purification*
  • Sequence Analysis, DNA
  • Tuberculosis, Multidrug-Resistant / diet therapy
  • Tuberculosis, Multidrug-Resistant / epidemiology
  • Tuberculosis, Multidrug-Resistant / genetics*
  • Tuberculosis, Multidrug-Resistant / immunology

Substances

  • Antitubercular Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • Catalase
  • katG protein, Mycobacterium tuberculosis
  • Hydrolases
  • HsaD protein, Mycobacterium tuberculosis