Abstract
Of 75 MDR isolates from Fujian Province, the sensitivity of RIF, INH, EMB, SM, OFLX and KAN resistance by DNA sequencing was 96.0%, 96.0%, 66.7%, 66.0%, 84.2% and 75.0%, respectively. We also identified that minority mutations in the mixed Mycobacterium tuberculosis population may be responsible for two "false-negative" results. In addition, Beijing genotype is still the predominant sublineage in the MDR TB cases from Fujian.
Keywords:
MDR; Molecular characteristics; Mycobacterium tuberculosis.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antitubercular Agents / pharmacology*
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Bacterial Proteins / drug effects
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Bacterial Proteins / genetics*
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Bacterial Proteins / immunology
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Bacterial Proteins / isolation & purification
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Catalase / drug effects
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Catalase / genetics*
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Catalase / immunology
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China / epidemiology
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DNA, Bacterial / isolation & purification
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Drug Resistance, Bacterial / genetics
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False Negative Reactions
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Female
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Gene Deletion
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Humans
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Hydrolases / drug effects
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Hydrolases / genetics*
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Hydrolases / immunology
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mutation
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / immunology
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Mycobacterium tuberculosis / isolation & purification*
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Sequence Analysis, DNA
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Tuberculosis, Multidrug-Resistant / diet therapy
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Tuberculosis, Multidrug-Resistant / epidemiology
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Tuberculosis, Multidrug-Resistant / genetics*
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Tuberculosis, Multidrug-Resistant / immunology
Substances
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Antitubercular Agents
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Bacterial Proteins
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DNA, Bacterial
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Catalase
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katG protein, Mycobacterium tuberculosis
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Hydrolases
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HsaD protein, Mycobacterium tuberculosis