Abstract
(-)-Tulipalin B and (+)-6-tuliposide B were confirmed to inhibit MurA in vitro. However, contrary to fosfomycin, these compounds showed potent inhibitory activities against MurA overexpressing Escherichia coli, especially in the presence of UDP-GlcNAc. These observations suggest that these compounds induced bacterial cell death not through a MurA malfunction, but in such a MurA-mediated indirect manner as the inhibition of other Mur enzymes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / pharmacology
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Alkyl and Aryl Transferases / antagonists & inhibitors*
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Alkyl and Aryl Transferases / genetics
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Enzyme Inhibitors / pharmacology*
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Escherichia coli / genetics
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Escherichia coli / metabolism
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Glucosides / pharmacology*
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Hydroxybutyrates / pharmacology*
Substances
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6-tuliposide B
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Enzyme Inhibitors
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Glucosides
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Hydroxybutyrates
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tulipalin B
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Alkyl and Aryl Transferases
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UDP-N-acetylglucosamine 1-carboxyvinyltransferase
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4-Butyrolactone