Simultaneous sonication assistance for the synthesis of tetrahydropyridines and its efficient catalyst ZrP2O7 nanoparticles

Abdollah Javidan; Abolfazl Ziarati; Javad Safaei-Ghomi

doi:10.1016/j.ultsonch.2013.11.011

Simultaneous sonication assistance for the synthesis of tetrahydropyridines and its efficient catalyst ZrP2O7 nanoparticles

Ultrason Sonochem. 2014 May;21(3):1150-4. doi: 10.1016/j.ultsonch.2013.11.011. Epub 2013 Nov 27.

Authors

Abdollah Javidan¹, Abolfazl Ziarati², Javad Safaei-Ghomi³

Affiliations

¹ Chemistry Department, Imam Hossein University, P.O. Box 16575-347, Tehran, Iran. Electronic address: Ajavidan@ihu.ac.ir.
² Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 51167, Iran.
³ Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 51167, Iran. Electronic address: safaei@kashanu.ac.ir.

PMID: 24315669
DOI: 10.1016/j.ultsonch.2013.11.011

Abstract

In this research, a general synthetic method for the synthesis of tetrahydropyridines were developed using ZrP2O7 nanoparticles under ultrasonic irradiations. Firstly by a simple and green process, nano zirconium pyrophosphate was prepared via sonication. Subsequently, this nanoparticle was used as an efficient catalyst for the synthesis of highly functionalized tetrahydropyridines via five-component reaction of aromatic aldehyde, amine and ethyl acetoacetate in ethanol under ultrasound irradiation. The present approach offers several advantages such as high yields, environmentally benign, simple work-up, excellent yield of products, short reaction times as well as recoverability and reusability of the catalyst.

Keywords: Green chemistry; Multicomponent reactions; Tetrahydropyridines; Ultrasonic irradiation; ZrP(2)O(7) nanoparticles.

Publication types

Research Support, Non-U.S. Gov't