Non-quinolone inhibitors of bacterial type IIA topoisomerases: a feat of bioisosterism

Chem Rev. 2014 Feb 26;114(4):2313-42. doi: 10.1021/cr4003984. Epub 2013 Dec 6.

Authors

Claudine Mayer¹, Yves L Janin

Affiliation

¹ Unité de Microbiologie Structurale, Département de Biologie Structurale et Chimie, Institut Pasteur , 25 rue du Dr. Roux, 75724 Paris Cedex 15, France.

PMID: 24313284
DOI: 10.1021/cr4003984

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacteria / enzymology
Catalytic Domain
Coumarins / chemistry
Coumarins / metabolism
DNA Topoisomerases, Type II / chemistry*
DNA Topoisomerases, Type II / metabolism
Peptides, Cyclic / chemistry
Peptides, Cyclic / metabolism
Protein Binding
Protein Structure, Tertiary
Quinolones / chemistry
Topoisomerase II Inhibitors / chemistry*
Topoisomerase II Inhibitors / metabolism

Substances

Coumarins
Peptides, Cyclic
Quinolones
Topoisomerase II Inhibitors
cyclothialidine
DNA Topoisomerases, Type II