Synthesis, characterization, and evaluation of radiometal-containing peptide nucleic acids

Methods Mol Biol. 2014:1050:37-54. doi: 10.1007/978-1-62703-553-8_4.

Abstract

Peptide nucleic acids (PNAs) have very attractive properties for applications in nuclear medicine. Because PNAs have high selectivity for DNA/RNA recognition, resistance to nuclease/protease degradation, and high thermal and radiolytic stabilities, PNA bioconjugates could transform the areas of diagnostic and therapeutic nuclear medicine. In this book chapter, we report on the current developments towards the preparation of radiometal-containing PNA constructs and summarize the protocols for labeling these probes with (99m)Tc, (111)In, (64)Cu, (90)Y, and (177)Lu.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chemistry Techniques, Synthetic / methods*
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Isotope Labeling
  • Metals / chemistry*
  • Peptide Nucleic Acids / chemical synthesis*
  • Peptide Nucleic Acids / chemistry*
  • Peptide Nucleic Acids / genetics
  • Pyridines / chemistry
  • Radioisotopes / chemistry

Substances

  • Heterocyclic Compounds, 1-Ring
  • Metals
  • Peptide Nucleic Acids
  • Pyridines
  • Radioisotopes
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • pyridine