The generation of autologous pluripotent stem cells by reprogramming and then their differentiation into any cell type is a very attractive prospect for biomedicine. Additionally, if it were possible to repair malfunctioning genes it would mean that there is hope for patients suffering from incurable diseases in which conventional treatment does not give satisfactory results. Data from animal models are promising. But there are still issues that must be solved, such as the low efficiency of the derivation of induced pluripotent cells, and most importantly, making sure that the techniques used both for reprogramming cells, as well as for gene therapy are safe.