Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis

Appl Radiat Isot. 2014 Feb:84:40-7. doi: 10.1016/j.apradiso.2013.10.020. Epub 2013 Nov 11.

Abstract

Microfluidic systems are currently receiving a lot of attention in the PET radiochemistry field, due to their demonstrated ability to obtain higher incorporation yields with reduced total processing time and using a decreased amount of precursors. The Advion NanoTek LF was the first commercial microfluidic system available for radiochemistry that allows basic parameter optimization to be performed. In this paper we report hardware and software modifications that would allow better performing procedures, higher product throughput and flexibility to utilize the system. In particular, HPLC purification and SPE formulation have been fully integrated.

Keywords: (18)F-fluoride; Advion NanoTek; Dose On Demand; Microfluidic radiochemistry; PET.

MeSH terms

  • Chromatography, High Pressure Liquid / methods
  • Equipment Design
  • Fluorine Radioisotopes
  • Isotope Labeling / methods*
  • Microfluidic Analytical Techniques / instrumentation*
  • Microfluidics / instrumentation
  • Positron-Emission Tomography / instrumentation
  • Positron-Emission Tomography / methods
  • Radiochemistry / methods
  • Radiopharmaceuticals / chemical synthesis*
  • Software
  • Solid Phase Extraction

Substances

  • Fluorine Radioisotopes
  • Radiopharmaceuticals