Multivariate meta-analysis: a method to summarize non-linear associations

Abstract

Multivariate meta-analysis represents a promising statistical tool in several research areas. Here, we provide a brief overview of the application of this methodology to combining complex multi-parameterized relationships, such as non-linear or delayed associations, in multi-site studies. The discussion focuses on the advantages over simpler univariate methods, estimation and computational issues and directions for further research.

Keywords: exposure-response; multivariate meta-analysis; non-linear.