Abstract
Three new diphenylpropanes, Hindsiipropane A-C (1-3), together with one known arylpropyl quinone Griffithane D (4), were isolated from Celastrus hindsii. Their structures were established by 1D and 2D nuclear magnetic resonance spectroscopic analysis, and mass spectroscopy. Compound 4 was firstly obtained in this genus. All the isolated compounds were evaluated in vitro for cytotoxicity against four human tumor cell lines (A549, HCT116, MDA-MB-231, BEL7404) by the MTT assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Biphenyl Compounds / isolation & purification*
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Biphenyl Compounds / pharmacology
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Celastrus / chemistry*
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Plant Stems / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Spectroscopy, Fourier Transform Infrared
Substances
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Antineoplastic Agents, Phytogenic
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Biphenyl Compounds