Contribution of long noncoding RNAs to autism spectrum disorder risk

Brent Wilkinson; Daniel B Campbell

doi:10.1016/B978-0-12-418700-9.00002-2

Contribution of long noncoding RNAs to autism spectrum disorder risk

Int Rev Neurobiol. 2013:113:35-59. doi: 10.1016/B978-0-12-418700-9.00002-2.

Authors

Brent Wilkinson¹, Daniel B Campbell

Affiliation

¹ Program in Biological and Biomedical Sciences, University of Southern California, Los Angeles, California, USA; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.

PMID: 24290382
DOI: 10.1016/B978-0-12-418700-9.00002-2

Abstract

Accumulating evidence indicates that long noncoding RNAs (lncRNAs) contribute to autism spectrum disorder (ASD) risk. Although a few lncRNAs have long been recognized to have important functions, the vast majority of this class of molecules remains uncharacterized. Because lncRNAs are more abundant in human brain than protein-coding RNAs, it is likely that they contribute to brain disorders, including ASD. We review here the known functions of lncRNAs and the potential contributions of lncRNAs to ASD.

Keywords: Biomarkers; Epigenetics; Gene regulation; Long noncoding RNA; Noncoding RNA; Transcriptional regulation; lncRNA; ncRNA.

Publication types

Review

MeSH terms

Child Development Disorders, Pervasive / genetics*
Gene Expression Regulation / genetics
Genetic Predisposition to Disease / genetics*
Humans
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding

Grants and funding

R01 MH100172/MH/NIMH NIH HHS/United States