Impact of Next-Generation Sequencing (NGS) technology on cardiovascular disease research

Fengping Xu; Qin Wang; Fangfang Zhang; Yinling Zhu; Qingquan Gu; Liping Wu; Lin Yang; Xu Yang

doi:10.3978/j.issn.2223-3652.2012.06.01

Impact of Next-Generation Sequencing (NGS) technology on cardiovascular disease research

Cardiovasc Diagn Ther. 2012 Jun;2(2):138-46. doi: 10.3978/j.issn.2223-3652.2012.06.01.

Authors

Fengping Xu¹, Qin Wang, Fangfang Zhang, Yinling Zhu, Qingquan Gu, Liping Wu, Lin Yang, Xu Yang

Affiliation

¹ BGI-Shenzhen, Shenzhen, China.

PMID: 24282707
PMCID: PMC3839151
DOI: 10.3978/j.issn.2223-3652.2012.06.01

Abstract

In recent years, hundreds of gene loci associated with multiple cardiovascular pathologies and traits have been identified through high-throughput Next-Generation Sequencing (NGS) technology. Due to the increasing efficiency and decreasing cost of NGS, rapid progresses anticipated in the field of CVD research. This review summarizes the main strategies of CV research with NGS at the level of genomics, transcriptomics, epigenetics, and proteomics.

Keywords: Cardiovascular disease; Next-Generation Sequencing; epigenetics; genomics; proteomics.

Publication types

Review