Heteronuclear gold(I)-silver(I) sulfanylcarboxylates: Synthesis, structure and cytotoxic activity against cancer cell lines

J Inorg Biochem. 2014 Feb:131:68-75. doi: 10.1016/j.jinorgbio.2013.10.022. Epub 2013 Nov 1.

Abstract

Heteronuclear complexes of the type [AgAu(PPh3)2(xspa)] [H2xspa=3-(aryl)-2-sulfanylpropenoic acids; (x=3-phenyl-; 3-(2-chlorophenyl)-; 3-(o-methoxyphenyl)-; 3-(p-methoxyphenyl)-; 3-(p-hydroxyphenyl)-; 3-(2-furyl)-; 3-(2-thienyl)-; spa=2-sulfanylpropenoate)] were prepared by reacting the appropriate [Au(PPh3)(Hxspa)] precursor with Ag(PPh3)NO3. The compounds were characterized by spectroscopic methods, (IR; (1)H, (13)C and (31)P NMR) and mass spectrometry and the structures of the phenyl and p-methoxyphenyl derivatives were determined by X-ray diffraction. The in vitro antitumor activity against the HeLa-229, A2780 and A2780cis cell lines was determined and compared with that of cisplatin and the equivalent homonuclear gold(I) complexes.

Keywords: Cytotoxic activity; Gold(I) complexes; Heteronuclear complexes; Silver(I) complexes; Sulfanylpropenoic acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Carboxylic Acids / chemistry
  • Chemistry Techniques, Synthetic
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • HeLa Cells / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Organogold Compounds / chemical synthesis
  • Organogold Compounds / chemistry*
  • Organogold Compounds / pharmacology*
  • Silver Compounds / chemical synthesis
  • Silver Compounds / chemistry*
  • Silver Compounds / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Carboxylic Acids
  • Organogold Compounds
  • Silver Compounds