Divergent transcription: a driving force for new gene origination?

Cell. 2013 Nov 21;155(5):990-6. doi: 10.1016/j.cell.2013.10.048.

Abstract

The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Evolution, Molecular
  • Genome
  • Humans
  • RNA, Untranslated / genetics*
  • Regulatory Sequences, Nucleic Acid*
  • Transcription, Genetic*

Substances

  • RNA, Untranslated