1,3-Carbothiolation of 4-(trifluoromethyl)-p-quinols: a new access to functionalized (trifluoromethyl)arenes

Xiao Liu; Ling Pan; Jinhuan Dong; Xianxiu Xu; Qian Zhang; Qun Liu

doi:10.1021/ol403096g

1,3-Carbothiolation of 4-(trifluoromethyl)-p-quinols: a new access to functionalized (trifluoromethyl)arenes

Org Lett. 2013 Dec 20;15(24):6242-5. doi: 10.1021/ol403096g. Epub 2013 Nov 21.

Authors

Xiao Liu¹, Ling Pan, Jinhuan Dong, Xianxiu Xu, Qian Zhang, Qun Liu

Affiliation

¹ Department of Chemistry, Northeast Normal University , Changchun 130024, China.

PMID: 24261717
DOI: 10.1021/ol403096g

Abstract

A new strategy, the 1,3-carbothiolation/aromatization, for the synthesis of functionalized (trifluoromethyl)arenes has been developed that enables the regioselective introduction of two different functional groups onto an "aromatic ring" in the meta-position to each other in a single step.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrocarbons, Fluorinated / chemical synthesis*
Hydrocarbons, Fluorinated / chemistry
Hydroquinones / chemistry*
Molecular Structure
Sulfhydryl Compounds / chemical synthesis*
Sulfhydryl Compounds / chemistry

Substances

Hydrocarbons, Fluorinated
Hydroquinones
Sulfhydryl Compounds