One-pot three-component approach to the synthesis of polyfunctional pyrazoles

Org Lett. 2013 Dec 6;15(23):5967-9. doi: 10.1021/ol402810f. Epub 2013 Nov 20.

Abstract

A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Combinatorial Chemistry Techniques
  • Hydrazines / chemistry*
  • Molecular Structure
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Stereoisomerism

Substances

  • Aldehydes
  • Hydrazines
  • Pyrazoles