Complete genome analysis of a rare human G3P[9] rotavirus posing as an AU-1 like strain

Apiradee Theamboonlers; Ornwalan Maiklang; Thanunrat Thongmee; Thaweesak Chieochansin; Viboonsuk Vuthitanachot; Yong Poovorawan

doi:10.1186/2193-1801-2-569

Complete genome analysis of a rare human G3P[9] rotavirus posing as an AU-1 like strain

Springerplus. 2013 Oct 26:2:569. doi: 10.1186/2193-1801-2-569. eCollection 2013.

Authors

Apiradee Theamboonlers¹, Ornwalan Maiklang, Thanunrat Thongmee, Thaweesak Chieochansin, Viboonsuk Vuthitanachot, Yong Poovorawan

Affiliation

¹ Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and Hospital, Bangkok, 10330 Thailand.

Abstract

Background: We performed phylogenetic and sequence analysis by Basic Local Alignment Search Tool (BLAST) of a complete Human Rotavirus (HRV) genome isolated from a hospitalized child with acute gastroenteritis in Thailand.

Findings: The results indicated an uncommon strain characterized by multiple re-assortments in the VP3, VP4, VP6, NSP1, NSP4 and NSP5 genes. The uncommon strain is genotype G3-P[9]-I3-R3-C3-M3-A3-N3-T3-E3-H6, which displays aspects of the AU-1, FRV-1 and corresponds to the feline/canine prototype G3P[9] strain.

Conclusions: The results suggested that nearly all the eleven gene segments of G3P[9] RVA strain CU365 might have originated from feline/canine RVAs (Rotavirus A).

Keywords: AU-1 like strain; G3P[9]; Human rotavirus (HRV); Uncommon strain.

Publication types

Case Reports