Carbohydrate recognition by rotaviruses

J Struct Funct Genomics. 2014 Sep;15(3):101-6. doi: 10.1007/s10969-013-9167-5. Epub 2013 Nov 19.

Abstract

Rotaviruses are a global health concern causing severe childhood diarrhea. Though the mechanisms mediating rotavirus cell entry require further characterisation, it is acknowledged that an essential and critical step in rotavirus infection is the virus cell attachment via initial recognition of cell surface carbohydrate-containing receptors. This review summarises the current knowledge about recognition of glycan receptors by rotaviruses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Crystallography, X-Ray
  • Diarrhea / virology
  • Humans
  • N-Acetylneuraminic Acid / metabolism
  • Neuraminic Acids / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • RNA-Binding Proteins / ultrastructure*
  • Receptors, Virus / metabolism*
  • Rotavirus / genetics*
  • Rotavirus Infections / virology
  • Viral Nonstructural Proteins / genetics
  • Viral Nonstructural Proteins / metabolism
  • Viral Nonstructural Proteins / ultrastructure*
  • Virus Attachment*
  • Virus Internalization

Substances

  • Neuraminic Acids
  • RNA-Binding Proteins
  • Receptors, Virus
  • Viral Nonstructural Proteins
  • N-glycolylneuraminic acid
  • NS35 protein, rotavirus
  • N-Acetylneuraminic Acid