Pediatric Guillain-Barré syndrome

Curr Opin Pediatr. 2013 Dec;25(6):689-93. doi: 10.1097/MOP.0b013e328365ad3f.

Abstract

Purpose of review: Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in children. This review discusses the heterogeneous presentations of this disorder, the frequency of disease-related complications and the importance of assiduous clinical care in pediatric GBS.

Recent findings: Recent reports have highlighted the variable clinical and neurophysiologic subtypes of pediatric GBS, and emphasized the value of imaging in diagnosis of this disorder.

Summary: Diagnosis of pediatric GBS is often delayed because of its variable presentation. Early recognition and treatment decrease long-term morbidity and mortality. Recent research has cast light on the variable presentations and pathogenesis of the numerous subtypes of this condition, and is now focusing upon a better understanding of the natural history of GBS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Distribution
  • Autoantibodies
  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Disease Progression
  • Early Diagnosis
  • Female
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Guillain-Barre Syndrome / complications
  • Guillain-Barre Syndrome / diagnosis*
  • Guillain-Barre Syndrome / genetics*
  • Guillain-Barre Syndrome / therapy
  • Humans
  • Hypotension / genetics*
  • Immunoglobulins, Intravenous / therapeutic use*
  • Infant
  • Male
  • Prognosis
  • Respiration, Artificial
  • Respiratory Insufficiency / diagnosis*
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / genetics
  • Respiratory Insufficiency / therapy
  • Time Factors

Substances

  • Autoantibodies
  • Immunoglobulins, Intravenous