Towards fabrication of 3D printed medical devices to prevent biofilm formation

Int J Pharm. 2014 Jan 1;459(1-2):62-4. doi: 10.1016/j.ijpharm.2013.11.001. Epub 2013 Nov 12.

Abstract

The use of three-dimensional (3D) printing technologies is transforming the way that materials are turned into functional devices. We demonstrate in the current study the incorporation of anti-microbial nitrofurantoin in a polymer carrier material and subsequent 3D printing of a model structure, which resulted in an inhibition of biofilm colonization. The approach taken is very promising and can open up new avenues to manufacture functional medical devices in the future.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Attachment Sites, Microbiological / drug effects
  • Biofilms / drug effects
  • Biofilms / growth & development*
  • Equipment Design*
  • Equipment and Supplies*
  • Health Care Sector
  • Indicators and Reagents
  • Microbial Sensitivity Tests
  • Nitrofurantoin / administration & dosage
  • Nitrofurantoin / chemistry
  • Nitrofurantoin / pharmacology
  • Oxazines / administration & dosage
  • Oxazines / chemistry
  • Printing
  • Spectrophotometry, Ultraviolet
  • Staphylococcus aureus / drug effects
  • Xanthenes / administration & dosage
  • Xanthenes / chemistry

Substances

  • Anti-Bacterial Agents
  • Indicators and Reagents
  • Oxazines
  • Xanthenes
  • resazurin
  • Nitrofurantoin