Optimal mapping of x-ray laser diffraction patterns into three dimensions using routing algorithms

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Oct;88(4):042710. doi: 10.1103/PhysRevE.88.042710. Epub 2013 Oct 28.

Abstract

Coherent diffractive imaging with x-ray free-electron lasers (XFEL) promises high-resolution structure determination of noncrystalline objects. Randomly oriented particles are exposed to XFEL pulses for acquisition of two-dimensional (2D) diffraction snapshots. The knowledge of their orientations enables 3D imaging by multiview reconstruction, combining 2D diffraction snapshots in different orientations. Here we introduce a globally optimal algorithm that can infer these orientations. We apply it to experimental XFEL data of nanoparticles and so determine their 3D electron density.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Image Processing, Computer-Assisted / methods*
  • Lasers*
  • Photons
  • Rotation
  • X-Ray Diffraction*