Carbapenem de-escalation therapy in a resource-limited setting

Infect Control Hosp Epidemiol. 2013 Dec;34(12):1310-3. doi: 10.1086/673976. Epub 2013 Oct 24.

Abstract

Pulmonary infection (P=.01) and an infectious diseases consultation (P=.04) were associated with carbapenem de-escalation; pulmonary infection and septic shock were associated with unsuccessful de-escalation. Successful de-escalation was associated with lower mortality (0% vs 23%; P<.001) and shorter duration of carbapenem use (4 vs 10 days; P ≤ .001).

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use*
  • Carbapenems / therapeutic use*
  • Female
  • Gentian Violet
  • Gram-Negative Bacterial Infections / drug therapy*
  • Gram-Positive Bacterial Infections / drug therapy*
  • Humans
  • Lung Diseases / drug therapy
  • Lung Diseases / microbiology
  • Male
  • Middle Aged
  • Phenazines
  • Referral and Consultation
  • Shock, Septic / drug therapy
  • Thailand
  • Urinary Tract Infections / drug therapy
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Gram's stain
  • Phenazines
  • Gentian Violet