Enzymatic "click" ligation: selective cysteine modification in polypeptides enabled by promiscuous glutathione S-transferase

Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14001-5. doi: 10.1002/anie.201306430. Epub 2013 Nov 12.
No abstract available

Keywords: bioconjugation; click chemistry; cysteine arylation; enzyme catalysis; peptide macrocyclization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Click Chemistry
  • Cysteine / chemistry*
  • Glutathione Transferase / chemistry*
  • Humans
  • Peptides
  • Protein Processing, Post-Translational

Substances

  • Peptides
  • Glutathione Transferase
  • Cysteine