Novel methods for liposome preparation

Yogita P Patil; Sameer Jadhav

doi:10.1016/j.chemphyslip.2013.10.011

Novel methods for liposome preparation

Chem Phys Lipids. 2014 Jan:177:8-18. doi: 10.1016/j.chemphyslip.2013.10.011. Epub 2013 Nov 9.

Authors

Yogita P Patil¹, Sameer Jadhav²

Affiliations

¹ Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.
² Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India. Electronic address: srjadhav@iitb.ac.in.

PMID: 24220497
DOI: 10.1016/j.chemphyslip.2013.10.011

Abstract

Liposomes are bilayer vesicles which have found use, among other applications, as drug delivery vehicles. Conventional techniques for liposome preparation and size reduction remain popular as these are simple to implement and do not require sophisticated equipment. However, issues related to scale-up for industrial production and scale-down for point-of-care applications have motivated improvements to conventional processes and have also led to the development of novel routes to liposome formation. In this article, these modified and new methods for liposome preparation have been reviewed and classified with the objective of updating the reader to recent developments in liposome production technology.

Keywords: Electroformation; Microfluidic; Multilamellar; Supercritical fluid; Unilamellar.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Kinetics
Liposomes* / chemistry
Thermodynamics
Unilamellar Liposomes / chemistry

Substances

Liposomes
Unilamellar Liposomes