Abstract
A 45-year-old male with rhinocerebral mucormycosis (Rhizopus oryzae), refractory to liposomal amphotericin B and posaconazole, received isavuconazole salvage therapy. Initial isavuconazole plasma and tissue levels were 0.76-0.86 μg/mL and 1.09-1.38 μg/g. Plasma levels increased to 1.3-3.24 μg/mL with reduced comedication. Isavuconazole was well tolerated, and the patient has remained disease-free 24 months post-antifungal therapy.
MeSH terms
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Antifungal Agents / therapeutic use*
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Brain Diseases / drug therapy*
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Brain Diseases / microbiology
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Brain Diseases / surgery
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Humans
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Male
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Middle Aged
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Mucormycosis / drug therapy*
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Mucormycosis / microbiology
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Mucormycosis / surgery
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Nitriles / therapeutic use*
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Pyridines / therapeutic use*
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Rhizopus / genetics
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Rhizopus / isolation & purification*
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Rhizopus / physiology
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Salvage Therapy
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Treatment Outcome
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Triazoles / therapeutic use*
Substances
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Antifungal Agents
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Nitriles
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Pyridines
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Triazoles
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isavuconazole