Assessing therapy response of secreting pineal germ cell tumor on simultaneous 18F-choline PET/MRI

Clin Nucl Med. 2014 Sep;39(9):e387-8. doi: 10.1097/RLU.0000000000000231.

Abstract

An 18-year-old man presented with 6 weeks' history of diplopia, early morning headaches, and blurred vision; on ophthalmologic examination, Parinaud syndrome was revealed. Brain MRI scan showed a calcified pineal mass. Brain simultaneous PET/MRI with 18F-choline showed an avid enhancing mass occupying the pineal region with restricted diffusion. A second examination after chemotherapy demonstrated reduction in both size and radiotracer activity of the mass. Our study emphasizes the potential of simultaneous 18F-choline PET/MRI being a useful tool for contribution in the diagnosis and treatment assessment in a convenient way with minimal radiation exposure and reduced throughput patient time.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / pathology
  • Choline / analogs & derivatives
  • Cisplatin / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Etoposide / therapeutic use
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Multimodal Imaging
  • Neoplasms, Germ Cell and Embryonal / diagnostic imaging*
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / pathology
  • Pineal Gland / diagnostic imaging*
  • Pineal Gland / pathology
  • Pinealoma / diagnostic imaging*
  • Pinealoma / drug therapy
  • Pinealoma / pathology
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Treatment Outcome

Substances

  • Radiopharmaceuticals
  • fluoromethylcholine
  • Etoposide
  • Cyclophosphamide
  • Choline
  • Cisplatin

Supplementary concepts

  • CCE protocol