Bubonic lymphogranuloma venereum with multidrug treatment failure

Int J STD AIDS. 2014 Mar;25(4):306-8. doi: 10.1177/0956462413501158. Epub 2013 Aug 28.

Abstract

A patient with proctitis and inguinal buboes diagnosed with lymphogranuloma venereum (LGV) was treated with doxycycline 21 days, azithromycin 20 days and moxifloxacin for a further 12 days because of progressive worsening of inguinal symptoms. Despite extensive antibiotic treatment, the inguinal LGV lesions persisted; however, the patient recovered spontaneously after three months.

Keywords: Chlamydia trachomatis; LGV; Sexually transmitted infection; bubo; lymphogranuloma venereum; treatment failure.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Aza Compounds / therapeutic use
  • Azithromycin / therapeutic use
  • Chlamydia trachomatis / genetics
  • Chlamydia trachomatis / isolation & purification*
  • Doxycycline / therapeutic use
  • Fluoroquinolones
  • Homosexuality, Male
  • Humans
  • Lymphogranuloma Venereum / diagnosis*
  • Lymphogranuloma Venereum / drug therapy*
  • Lymphogranuloma Venereum / microbiology
  • Male
  • Middle Aged
  • Moxifloxacin
  • Multilocus Sequence Typing
  • Proctitis / diagnosis*
  • Proctitis / drug therapy
  • Proctitis / microbiology
  • Quinolines / therapeutic use
  • Real-Time Polymerase Chain Reaction
  • Treatment Failure

Substances

  • Anti-Bacterial Agents
  • Aza Compounds
  • Fluoroquinolones
  • Quinolines
  • Azithromycin
  • Doxycycline
  • Moxifloxacin