Two-photon-triggered drug delivery in cancer cells using nanoimpellers

Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13813-7. doi: 10.1002/anie.201308647. Epub 2013 Nov 7.

Abstract

A therapy of cancer cells: Two-photon-triggered camptothecin delivery with nanoimpellers was studied in MCF-7 breast cancer cells. A fluorophore with a high two-photon absorption cross-section was first incorporated in the nanoimpellers. Fluorescence resonance energy transfer (FRET) from the fluorophore to the azobenzene moiety was demonstrated.

Keywords: azobenzene; cancer; drug delivery; mesoporous materials; two-photon excitation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry*
  • Drug Delivery Systems / methods*
  • Humans
  • Nanoparticles / chemistry*
  • Neoplasms

Substances

  • Azo Compounds
  • azobenzene