The purpose of the article was to study the bone reparative regeneration in disorders caused by the dehydration of organism. Studies were conducted on 72 white laboratory young male rats. The structural and metabolic displays of reparative osteogenesis were studied by means of histological research of defected area, morphometry of histological preparations by means of the computer programs "Video Test 5,0" and "Video size 5,0". Quantitative disorders of regenerated cellular composition were found on the 3-rd day. Atypical granulation tissue was found on the 15-th day. The delay of regeneration - on the 24th day. It was concluded that the inhibition of reparative osteogenesis occurred under the influence of dehydration. The strongest impact on the process of bone regeneration was caused by an extracellular dehydration.