Abstract
Giant salvinia (Salvinia molesta) is one of the most noxious invasive species in the world. Our bioactivity-guided fractionation of ethanol extract of giant salvinia led to the isolation of 50 compounds. Of the six new compounds (1-6), salviniol (1) is a rare abietane diterpene with a new ferruginol-menthol coupled skeleton and both salviniside I (2) and salviniside II (3) are novel benzofuran glucose conjugates with unique 10-membered macrodiolide structures. Sixteen abietane diterpenes (1, 7-17, and 19-22) demonstrated in vitro activities against human tumor cells, and 7 and 8 showed selective cytotoxicity to tumor cells over normal cells.
Keywords:
Abietane diterpenes; Cytotoxicity; Giant salvinia; Invasive species; Salvinia molesta; Salviniol; Salviniside.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Abietanes / chemistry*
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Abietanes / isolation & purification
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Abietanes / toxicity*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity*
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Benzofurans / chemistry*
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Benzofurans / isolation & purification
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Benzofurans / toxicity
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / toxicity
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / toxicity
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Humans
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Introduced Species
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Macrolides / chemistry*
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Macrolides / isolation & purification
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Macrolides / toxicity
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Magnetic Resonance Spectroscopy
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Menthol / chemistry
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Molecular Conformation
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Plant Extracts / toxicity*
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Tracheophyta / chemistry*
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Tracheophyta / metabolism
Substances
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Abietanes
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Antineoplastic Agents, Phytogenic
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Benzofurans
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Diterpenes
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Glucosides
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Macrolides
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Plant Extracts
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ferruginol
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salviniol
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Menthol