Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum

Phytochemistry. 2013 Dec:96:360-9. doi: 10.1016/j.phytochem.2013.10.005. Epub 2013 Nov 5.

Abstract

Sixteen daphnane diterpenoids, trigothysoids A-P, along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thyrsoideum. Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619.

Keywords: Anti-HIV-1; Daphnane diterpenoids; Euphorbiaceae; Trigonostemon thyrsoideum; Trigothysoids A−P.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Euphorbiaceae / chemistry*
  • HIV-1 / drug effects
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Leaves
  • Plant Stems / chemistry

Substances

  • Anti-HIV Agents
  • Diterpenes
  • Drugs, Chinese Herbal
  • mezerein