Advances in lung preservation

Abstract

After a brief review of conventional lung preservation, this article discusses the rationale behind ex vivo lung perfusion and how it has shifted the paradigm of organ preservation from conventional static cold ischemia to the utilization of functional normothermia, restoring the lung's own metabolism and its reparative processes. Technical aspects and previous clinical experience as well as opportunities to address specific donor organ injuries in a personalized medicine approach are also reviewed.

Keywords: Ex vivo lung perfusion; Lung transplantation; Non–heart beating donor; Organ preservation; Organ procurement.